21700 batteries are bigger in size when compared to the commonly used 18650, but with this comes much higher options for capacity. Comparing Mah (used to measure a battery's capacity), 18650s range from 2000Mah - 3000Mah, whereas 21700 cells can get you up to 4200Mah. The end result is a vape that can run much longer, and keep down time to a minimum.
Always check the product page to see if your device needs batteries, and if so which size is compatible.